Case report, 1999
Can LHRH analogue prevent premenstrual attacks of acute intermittent porphyria?
Yes. In this one woman, an LHRH analogue combined with low-dose oestrogen patch stopped her premenstrual attacks and she has not needed hospitalization for over 3 years.
What they did
Case report of a 38-year-old woman with acute intermittent porphyria. She had suffered several premenstrual attacks with severe symptoms like abdominal pain and paralysis. Different treatments were tried over time. Eventually she was treated with an LHRH analogue combined with low-dose oestrogen patch.
What they found
The premenstrual attacks stopped after she started the LHRH analogue and oestrogen patch. She has not needed hospitalization for over 3 years since starting this treatment.
What it means for you
Stopping hormone changes with an LHRH analogue may prevent this condition from worsening before the period. This is one woman's experience, so we do not know if it works for other people.
38
age in years
29
age when first porphyria attack occurred
over 3 years
time without hospitalization
About the study
- Original title
- Premenstrual attacks of acute intermittent porphyria: hormonal and metabolic aspects - a case report
- Authors
- De Block CE, Leeuw IH, Gaal LF
- Journal
- European journal of endocrinology
- Year
- 1999
- Study design
- Case report
- What was tested
- LHRH analogue combined with low-dose oestrogen patch
- Read the paper
- doi.org/10.1530/eje.0.1410050
Topics
Related studies
Systematic review, 2023
What hormonal treatments have been tested for PMDD, menstrual migraine, and catamenial epilepsy?
Systematic review, 2007
What treatments work for premenstrual syndrome?
Randomised trial, 2003
What treatments work for PMS and PMDD?
Review, 2003
What treatments work best for PMS and PMDD?
Review, 2003
What role do hormones play in PMS and how should we treat it?
Randomised trial, 2002
What treatments work best for cyclical breast pain?