Systematic review, 2023
What hormonal treatments have been tested for PMDD, menstrual migraine, and catamenial epilepsy?
Hormonal treatments have been tested 56 times for premenstrual mood disorder, 21 times for menstrual migraine, and 8 times for catamenial epilepsy. Combined oral contraceptives were a frequent focus.
What they did
Scoping review of 85 human studies published between 1950 and 2021. Included studies of reproductive-aged females with natural menstrual cycles who received hormonal treatments and were measured across at least two menstrual cycle phases.
What they found
Exogenous hormone manipulations were tested for premenstrual mood disorder (56 trials), menstrual migraine (21 trials), and catamenial epilepsy (8 trials). Combined oral contraceptives containing drospirenone were specifically noted.
What it means for you
These three menstrual cycle-related brain disorders have overlapping hormonal mechanisms and could benefit from shared research approaches, but researchers in each field have historically worked independently. The main limitation is that the provided abstract is incomplete.
85
Studies reviewed
56
Trials for premenstrual mood disorder
21
Trials for menstrual migraine
About the study
- Original title
- A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: Studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy
- Authors
- Barone JC, Butler MP, Ross A et al.
- Journal
- Frontiers in neuroendocrinology
- Year
- 2023
- Study design
- Systematic review
- What was tested
- Exogenous hormone manipulation (various types, including combined oral contraceptives)
- Open access
- Yes
- Read the paper
- doi.org/10.1016/j.yfrne.2023.101098
Topics
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