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Survey study, 2004

How often does depression get worse before a woman's period?

Depressed women had 1.34 more symptoms that got worse before their period compared to other times. Older women were more likely to experience worsening symptoms.

Moderate study design 900 menstruating women ages 13 to 53 in Illinois; 58 with depressive disorders, 842 without

What they did

Cross-sectional study. 900 menstruating women ages 13 to 53 from Illinois completed psychiatric interviews and rated depression symptoms daily for two menstrual cycles. 58 women had depressive disorders and 842 were not depressed.

What they found

Depressed women had 1.34 symptoms that became worse premenstrually. Older women more often had symptoms worsen. Symptoms during the follicular phase were most severe for clinically depressed women, intermediate for subclinically depressed, and least severe for non-depressed. Only 56% of non-depressed women taking antidepressants were symptom-free all month; 44% still had symptoms premenstrually.

What it means for you

Premenstrual worsening of depression happens in some depressed women and is more common with older age. The study was limited to one U.S. state and does not explain why worsening happens.

900

Total women studied

1.34

Average extra symptoms worsening premenstrually

56%

Non-depressed women on antidepressants symptom-free all month

About the study

Original title
Premenstrual exacerbation of depressive disorders in a community-based sample in the United States
Authors
Hartlage SA, Brandenburg DL, Kravitz HM
Journal
Psychosomatic medicine
Year
2004
Study design
Survey study
Participants
900
What was tested
None. Some women were taking antidepressants.

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