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Case report, 1983

Can a hormone treatment stop psychosis that comes back with the menstrual cycle?

In this one woman, yes - her psychosis stopped coming back each month when she took danazol, a hormone-blocking drug. But this is one person's story, so we can't be sure it would work for others.

Early or limited evidence One 26-year-old woman with psychosis after childbirth and a family history of schizophrenia

What they did

The doctors describe one 26-year-old woman who had a psychotic episode after giving birth. She had a family history of schizophrenia. After that, her psychotic symptoms kept coming back each month, just before her period started. They treated her with danazol, a synthetic steroid that stops ovulation.

What they found

Before danazol treatment, her psychotic symptoms came back each month, just before her period started. When she took danazol, this monthly pattern was prevented.

What it means for you

This suggests that hormones related to the menstrual cycle might trigger psychosis in some women, and blocking ovulation might help. The main limit is that this is just one woman's experience - we don't know if it would work for others.

1

woman in the case

26

age in years

About the study

Original title
Psychosis and the menstrual cycle
Authors
Dennerstein L, Judd F, Davies B
Journal
The Medical journal of Australia
Year
1983
Study design
Case report
What was tested
Danazol (synthetic steroid that blocks ovulation)

Topics