Cohort study, 2006
Are specific genetic variations linked to PMDD?
No. This study found no significant association between eight common genetic variations in serotonin pathways and PMDD, suggesting these particular genetic variations are not major contributors to PMDD.
What they did
Researchers studied 53 women with PMDD (mean age 37.7 years) and 52 healthy control women (mean age 36.2 years). They tested them for eight genetic variations in genes that control serotonin, including genes for serotonin transporter, tryptophan hydroxylase, and monoamine oxidase A. They compared the frequency of genetic variants between the two groups.
What they found
None of the eight genetic variants showed any significant difference between women with PMDD and control women. No significant allelic distribution profiles were found in either group.
What it means for you
These particular serotonin-related genetic variations do not appear to play a major role in causing PMDD. This does not rule out other genes or other ways that biology might contribute to PMDD. Larger studies or studies of different genetic variants might find different results.
53
Women with PMDD
52
Control women
8
Genetic variations tested
About the study
- Original title
- Serotonin transporter, tryptophan hydroxylase, and monoamine oxidase A gene polymorphisms in premenstrual dysphoric disorder
- Authors
- Magnay JL, Ismail KM, Chapman G et al.
- Journal
- American journal of obstetrics and gynecology
- Year
- 2006
- Study design
- Cohort study
- Participants
- 53
- What was tested
- None
- Read the paper
- doi.org/10.1016/j.ajog.2006.06.087
Topics
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