Randomised trial, 2025
Does rimegepant prevent migraines around your period?
Rimegepant prevented perimenstrual migraines in 85% of cycles with no side effects in this small study of 5 women, but we need larger studies to be confident in these results.
What they did
Case series of 5 women aged 22-42 with episodic migraine and regular menstrual cycles. They took rimegepant 75 mg every other day starting 2 days before menstruation and continuing 2 days after menstruation. Patients kept daily headache diaries and were followed for 3-4 cycles.
What they found
Rimegepant prevented perimenstrual attacks in 17 of 20 cycles (85%) with no treatment-related side effects. However, only 1 patient (20%) had sustained reduction in overall monthly migraine days. Three patients (60%) experienced delayed migraine onset 3-7 days after menstruation rather than complete prevention.
What it means for you
Rimegepant appears promising for preventing migraines around your period and was well tolerated. However, this was a very small case series with only 5 women and no control group. Some women's migraines were delayed rather than prevented. Much larger randomized controlled trials are needed to confirm these findings.
5
women in study
85%
of cycles with prevented attacks
60%
experienced delayed migraine
About the study
- Original title
- Short-term prevention of perimenstrual migraine with rimegepant
- Authors
- Frank F, Schiefecker A, Kaltseis K et al.
- Journal
- The journal of headache and pain
- Year
- 2025
- Study design
- Randomised trial
- What was tested
- Rimegepant 75 mg orally disintegrating tablet every other day for 2 days before and 2 days after menstruation
- Open access
- Yes
- Read the paper
- doi.org/10.1186/s10194-025-02185-y
Topics
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