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Cohort study, 1997

Do migraines get worse at certain times in the menstrual cycle?

Only 20% of the women showed a significant relationship between their menstrual cycle and migraines. For those who did, the menstrual cycle explained a substantial amount of their migraine patterns, but the study suggests fewer women are substantially affected than previously thought.

Early or limited evidence 20 young women with migraine who did not meet criteria for menstrual migraine

What they did

20 women with migraine tracked their headaches, stress, and coping strategies daily for two complete menstrual cycles. Researchers used time-series statistics to test whether menstrual cycle phases predicted headache activity.

What they found

20% of participants showed significant relationships between menstrual cycle phases and headache activity. For these women, the menstrual cycle explained a substantial amount of variation in their headaches. Relationships between the menstrual cycle and stress processes were also found, but these were inconsistent across women.

What it means for you

Although some women's migraines vary with the menstrual cycle, the study suggests far fewer women are substantially affected than previously estimated in medical literature. The relationship between the cycle and stress may also vary from woman to woman, so the causes may be complex.

20

women studied

20%

showing menstrual cycle effect on migraines

2

menstrual cycles tracked

About the study

Original title
The menstrual cycle and migraine: a time-series analysis of 20 women migraineurs
Authors
Lokken C, Holm JE, Myers TC
Journal
Headache
Year
1997
Study design
Cohort study
Participants
20
What was tested
None (observational study)

Topics