Skip to content

Survey study, 2018

Does the menstrual cycle affect how the body responds to stress?

Women in the luteal phase show a stronger cortisol response to laboratory stress than women in the follicular phase.

Early or limited evidence 42 women not on hormonal contraceptives (24 in follicular phase, 18 in luteal phase)

What they did

42 women not on hormonal contraceptives (24 in follicular phase, 18 in luteal phase) provided saliva samples during a normal day and during a stressful virtual reality task. Researchers measured cortisol in the saliva.

What they found

Women in the luteal phase had higher cortisol after the stress task (5.96 nmol/L) compared to women in the follicular phase (4.31 nmol/L). No other clear differences in daily cortisol patterns were found between the phases.

What it means for you

This suggests the body's stress response may be stronger in the luteal phase, possibly due to higher progesterone. This could affect how women experience stress throughout their cycle. The main limitation is the small sample size and the stress test was in a lab, so it may not reflect everyday stress.

42

women studied

5.96

cortisol nmol/L in luteal phase after stress

4.31

cortisol nmol/L in follicular phase after stress

About the study

Original title
The relationship between the menstrual cycle and cortisol secretion: Daily and stress-invoked cortisol patterns
Authors
Montero-López E, Santos-Ruiz A, García-Ríos MC et al.
Journal
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
Year
2018
Study design
Survey study
What was tested
Cortisol levels measured during stress exposure
Open access
Yes

Topics