Randomised trial, 1990
Does alprazolam help premenstrual dysphoria?
Yes. Alprazolam was significantly superior to placebo in treating late luteal phase dysphoric disorder based on physicians' ratings and patients' reports.
What they did
Double-blind, randomized crossover trial. 30 women with late luteal phase dysphoric disorder received alprazolam or placebo in random order. Outcomes were measured by physicians' global ratings and patients' daily prospective ratings and retrospective assessments. The study used extensive screening, placebo washout, and had women serve as their own controls.
What they found
Alprazolam was significantly superior to placebo based on physicians' global ratings and patients' prospective daily and retrospective assessments.
What it means for you
Alprazolam may help premenstrual dysphoria. The study's improved design with extensive screening, placebo washout, and prospective ratings may explain why they found a significant drug-placebo difference.
30
Women who completed the study
About the study
- Original title
- Treatment of premenstrual dysphoria with alprazolam. A controlled study
- Authors
- Harrison WM, Endicott J, Nee J
- Journal
- Archives of general psychiatry
- Year
- 1990
- Study design
- Randomised trial
- What was tested
- Alprazolam
- Read the paper
- doi.org/10.1001/archpsyc.1990.01810150070011
Topics
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