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Case-control study, 2012

Do women with PMDD have working memory problems linked to concentration and irritability?

Yes. Women with PMDD perform worse on working memory tasks during the luteal phase, and this decline is linked to difficulty concentrating, irritability, and reduced daily functioning.

Moderate study design 60 women with PMDD and 60 healthy controls

What they did

Case-control study of 60 women with PMDD and 60 healthy controls. Participants performed working memory tasks (N2 and N3 back tasks) during both luteal and follicular phases and reported symptom severity.

What they found

The PMDD group performed significantly worse on N2 and N3 back tasks during the luteal phase but not the follicular phase. Performance on these tasks was significantly associated with irritability, symptom severity, and functional impairment in the PMDD group.

What it means for you

Working memory problems during the luteal phase may explain why women with PMDD report concentration difficulties, which contributes to reduced daily functioning. Interventions to support memory and concentration could help manage symptoms.

60

women with PMDD

60

healthy controls

About the study

Original title
Working memory deficit in premenstrual dysphoric disorder and its associations with difficulty in concentrating and irritability
Authors
Yen JY, Chang SJ, Long CY et al.
Journal
Comprehensive psychiatry
Year
2012
Study design
Case-control study
Participants
60
What was tested
Working memory tasks

Topics