Review, 2006
Why do antidepressants work differently for PMDD than for general depression?
A theoretical model suggests PMDD responds faster to certain antidepressants (SSRIs) because it involves different brain mechanisms than depression. This framework has not yet been tested.
What they did
Theoretical review proposing an explanation for how antidepressant medicines (SSRIs) work in depression and PMDD.
What they found
Major depression may involve low dopamine from overly active 5-HT2 receptors. Antidepressants work by reducing these receptors, increasing dopamine. Female hormones may activate different 5-HT2 receptors causing atypical depression and premenstrual dysphoria. In PMDD, serotonin reuptake inhibitors may work through immediate serotonin increase rather than delayed receptor changes, explaining faster response. The model predicts 5-HT2 antagonists would work fast in melancholic depression and could speed serotonin reuptake inhibitor effects, but would interfere in atypical depression and premenstrual dysphoria.
What it means for you
PMDD and depression may involve different brain mechanisms, which could explain why PMDD responds faster to certain medications. Main limit: theoretical model, not yet tested.
About the study
- Original title
- A model to explain the therapeutic effects of serotonin reuptake inhibitors: the role of 5-HT2 receptors
- Authors
- Landén M, Thase ME
- Journal
- Psychopharmacology bulletin
- Year
- 2006
- Study design
- Review
- What was tested
- None
- Read the paper
- doi.org/10.64719/pb.4160
Topics
Related studies
Review, 2024
What are the most effective treatments for PMDD?
Randomised trial, 2004
Does dosing sertraline continuously or just before the period work better for severe PMS?
Randomised trial, 2004
What medications work for PMDD when taken only during the second half of the menstrual cycle?
Review, 2004
How should doctors diagnose and treat PMS and PMDD?
Randomised trial, 2000
How should PMDD be diagnosed and treated?
Randomised trial, 2000
Does sertraline improve how women with PMDD feel and function?