Survey study, 2023
Could treatments that affect the brain's GABA system help PMDD?
This review suggests GABA system changes may cause PMDD symptoms. Three compounds being tested in early clinical trials show promise, but much larger studies are needed to confirm if they work.
What they did
This was a literature review examining research on allopregnanolone (a brain chemical) and the GABA system's role in PMDD. It discussed several compounds being tested in early clinical trials for PMDD treatment.
What they found
The review found evidence that changes in allopregnanolone and GABA signaling during the luteal phase may cause mood problems in people susceptible to PMDD. Three compounds showed promising results in early clinical trials: dutasteride, isoallopregnanolone, and ulipristal acetate.
What it means for you
This review proposes a biological explanation for PMDD that could lead to new treatments. These are early findings discussed in a review article, not results from a large clinical trial. Much more research is needed to confirm if these compounds are safe and effective.
3
compounds with promising early trial results discussed
About the study
- Original title
- GABA-ergic Modulators: New Therapeutic Approaches to Premenstrual Dysphoric Disorder
- Authors
- Sikes-Keilp C, Rubinow DR
- Journal
- CNS drugs
- Year
- 2023
- Study design
- Survey study
- What was tested
- Compounds discussed in review (not tested): dutasteride, isoallopregnanolone, ulipristal acetate
- Read the paper
- doi.org/10.1007/s40263-023-01030-7
Topics
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