Study, 2026
How often do people have both PMDD and bipolar disorder together, and how do they affect each other?
PMDD and bipolar disorder frequently occur together, making mood episodes more frequent and severe. The connection appears to involve hormonal changes in estrogen and progesterone, though how well treatments work remains unclear.
What they did
Researchers searched medical literature databases (PubMed and Embase) up to June 2025 for studies on PMDD and bipolar disorder occurring together. They found and reviewed 18 papers - 13 original research studies and 5 clinical case reports.
What they found
PMDD and bipolar disorder frequently occurred together. When both were present, mood episodes happened more often and were more intense. The connections appeared to involve multiple factors, particularly hormonal changes in estrogen and progesterone. However, the review found that how well medicines, hormonal treatments, and therapy work for people with both conditions remains little studied.
What it means for you
PMDD and bipolar disorder together are common, but treatment approaches are not well studied. The hormones that drive PMS symptoms also appear to affect bipolar episodes. Care needs to address both hormonal cycles and mood. The main limitation is that the studies reviewed were varied, and treatment effectiveness has not been well studied.
18
articles reviewed
13
original studies
5
case reports
About the study
- Original title
- [Comorbidity of premenstrual dysphoric disorder and bipolar disorder: Characteristics and interactions]
- Authors
- Mongnet M, Korngold J, Masson M et al.
- Journal
- L'Encephale
- Year
- 2026
- Study design
- Study
- Participants
- 13
- What was tested
- Review of different medicines, hormonal approaches, and therapy (treatment effectiveness not systematically studied)
- Read the paper
- doi.org/10.1016/j.encep.2026.02.022
Topics
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