Non-randomised trial, 2011
Does a Chinese herbal medicine (Jingqianshu granule) help PMS by changing serotonin signaling in the brain?
In a study of PMS model rats, the herbal medicine increased serotonin receptor expression in key brain areas. However, this is an animal study and cannot be directly applied to humans with PMS.
What they did
Rats with an experimentally-induced PMS model (created by limb bandaging) were treated with Jingqianshu granule. Researchers tested the rats' behavior with an open-field test and measured serotonin receptor expression in brain tissue using molecular techniques.
What they found
After treatment with the herbal medicine, open-field test scores, serotonin receptor mRNA, and serotonin receptor protein expression in the hippocampus and hypothalamus all increased significantly.
What it means for you
This animal study suggests the herbal medicine may work by increasing serotonin signaling in specific brain regions. However, findings from animal studies cannot be directly applied to human PMS, and the study did not include a control group for comparison.
2
brain regions studied (hippocampus, hypothalamus)
About the study
- Original title
- [Effects of jingqianshu granule on expression of 5-HT(1A)R of PMS model rats with liver-qi stagnation]
- Authors
- Su Y, Xue L
- Journal
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Year
- 2011
- Study design
- Non-randomised trial
- What was tested
- Jingqianshu granule (Chinese herbal medicine)
- Read the paper
- doi.org/10.4268/cjcmm20112424
Topics
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