Randomised trial, 2022
Does lasmiditan help with migraines around menstruation?
Lasmiditan 200 mg helped more women achieve migraine pain freedom compared to placebo. At 2 hours, 33.6% of women taking the 200 mg dose had pain relief.
What they did
This was a pooled analysis of two randomized controlled trials (MONONOFU and CENTURION). A total of 303 women took a single dose of lasmiditan (50 mg, 100 mg, or 200 mg) or placebo and were checked for migraine pain relief up to 48 hours later.
What they found
More patients achieved migraine pain freedom with lasmiditan 200 mg versus placebo at all time points. At 2 hours, 33.6% of the 200 mg group had pain freedom compared to placebo. The 100 mg and 50 mg doses were also tested but 200 mg was the most effective.
What it means for you
Lasmiditan 200 mg appears to be a useful treatment for migraines that occur around menstruation. This analysis combined data from two trials so the evidence is reasonably strong, but it is a post-hoc analysis rather than a study designed specifically for perimenstrual migraine.
303
Women treated with lasmiditan or placebo
33.6%
Achieved pain freedom at 2 hours (200 mg group)
200 mg
Most effective dose tested
About the study
- Original title
- Efficacy of lasmiditan for the acute treatment of perimenstrual migraine
- Authors
- MacGregor EA, Komori M, Krege JH et al.
- Journal
- Cephalalgia : an international journal of headache
- Year
- 2022
- Study design
- Randomised trial
- Participants
- 303
- What was tested
- Lasmiditan 200 mg, 100 mg, or 50 mg versus placebo (single dose)
- Open access
- Yes
- Read the paper
- doi.org/10.1177/03331024221118929
Topics
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