Randomised trial, 2005

Can estrogen treat depression linked to hormonal changes?

Estrogen affects mood through brain chemistry, but there is not enough evidence to recommend it as a main treatment. SSRIs (a type of antidepressant) remain the standard choice.

Early or limited evidence Review of research on women with depression linked to reproductive events

What they did

This is a review of research from neuroscience and clinical trials about estrogen's effects on mood and its potential use for depression linked to hormonal changes (during the premenstrual phase, after childbirth, and around perimenopause).

What they found

Estrogen strengthens the serotonin system in the brain, which is involved in depression. Some randomized controlled trials found estrogen better than placebo for depression in perimenopausal women, but it only improved mood symptoms, not the full depressive syndrome. Using estrogen alongside antidepressants is promising but needs more research.

What it means for you

While estrogen clearly affects mood, we do not have enough evidence yet to recommend it as a first-line treatment for depression linked to hormonal changes. Antidepressants and psychotherapy remain the standard treatments. The main limit is that this is a review of existing evidence, not a new study.

About the study

Original title: Estrogen and Mood in Women
Authors: Barbara B. Sherwin
Journal: The Endocrinologist
Year: 2005
Study design: Randomised trial
What was tested: Estrogen treatment (in reviewed studies)
Read the paper: doi.org/10.1097/01.ten.0000162373.22576.7d

Topics

Premenstrual dysphoric disorder (PMDD)Menstrual cycle and mood Low mood and depression SSRIs and antidepressants Psychotherapy, counselling and education Major depressive disorder Perimenopause and menopause Pregnancy and postpartum

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