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Review, 2010

Does the menstrual cycle make mental and physical health problems worse?

Yes. Many medical and mental health conditions get worse at specific phases of the menstrual cycle, particularly during the luteal phase when premenstrual dysphoric disorder (a severe form of PMS) and depression commonly occur.

Early or limited evidence This is a review of research, not a study of specific women.

What they did

This is a review of research on how the menstrual cycle affects medical and mental health. The authors examined studies on worsening of various conditions during different cycle phases.

What they found

Many common health problems worsen at specific menstrual cycle phases. The menstrual cycle can trigger premenstrual dysphoric disorder and depression, both of which specifically occur during the luteal phase. The cause appears to involve complex interactions between the immune and hormone systems, though the exact cause is unclear.

What it means for you

If you have depression or other health conditions, your symptoms might get worse before your period. Doctors should screen for mental health problems at different cycle phases. Treatment options include antidepressants, therapy, and sometimes hormones.

About the study

Original title
Menstrual cycle-related exacerbation of disease
Authors
Pinkerton JV, Guico-Pabia CJ, Taylor HS
Journal
American journal of obstetrics and gynecology
Year
2010
Study design
Review
What was tested
Various treatments for menstrual cycle-related conditions
Open access
Yes

Topics