Case-control study, 2005
Is a specific gene (AP-2 beta) linked to PMDD?
No. This study found no difference in AP-2 beta genetic variants between women with PMDD and healthy women, suggesting this gene is not a risk factor for PMDD. However, the results should be confirmed in larger studies.
What they did
Case-control study comparing DNA of 176 women with PMDD and 91 healthy controls for a specific genetic variant (AP-2 beta polymorphism) with a variable number of repeats in the gene.
What they found
No differences were found in AP-2 beta genotype frequencies between women with PMDD and healthy controls.
What it means for you
This particular gene variant does not appear to be a risk factor for PMDD. Researchers studied this gene because it had been linked to the serotonin system, but it did not show a connection to PMDD. The authors note this is a negative finding and should be repeated in other studies before being considered final.
176
Women with PMDD
91
Healthy controls
About the study
- Original title
- Investigation of transcription factor AP-2 beta genotype in women with premenstrual dysphoric disorder
- Authors
- Damberg M, Westberg L, Berggård C et al.
- Journal
- Neuroscience letters
- Year
- 2005
- Study design
- Case-control study
- Participants
- 176
- What was tested
- Genetic testing for AP-2 beta gene polymorphism
- Read the paper
- doi.org/10.1016/j.neulet.2004.11.068
Topics
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