Randomised trial, 2011
Does myo-inositol help treat premenstrual dysphoric disorder symptoms?
Yes, myo-inositol significantly improved PMDD symptoms on three rating scales. Powder and capsule formulations worked similarly, though the study did not report how many women were treated.
What they did
Two-phase randomized trial with a placebo washout period followed by treatment comparison. Women with PMDD received either myo-inositol as powder or soft gel capsules, or placebo. The number of participants was not reported in the abstract.
What they found
Significant improvements were seen on the Daily Symptoms Records scale, Hamilton Depression Rating scale, and Clinical Global Impression-Severity scale. Both powder formulation (2 grams) and soft gel capsule formulation (0.6 grams) produced similar improvement.
What it means for you
Myo-inositol appears effective for PMDD, with two formulations available. However, the study lacks key information: how many women were treated, how long treatment lasted, and whether results persisted after treatment ended. This limits confidence in the findings.
2g
powder formulation dose
0.6g
soft gel capsule dose
3
rating scales showed improvement
About the study
- Original title
- Myo-inositol in the treatment of premenstrual dysphoric disorder
- Authors
- Gianfranco C, Vittorio U, Silvia B et al.
- Journal
- Human psychopharmacology
- Year
- 2011
- Study design
- Randomised trial
- What was tested
- Myo-inositol powder (2 grams) or soft gel capsules (0.6 grams)
- Read the paper
- doi.org/10.1002/hup.1241
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