Guideline, 2023
How are GnRH agonists used to treat PMDD that doesn't respond to standard medications?
GnRH agonists combined with hormone replacement are effective for severe PMDD that doesn't respond to first-line treatments, but many doctors don't know how to use this option.
What they did
This is a clinical guideline, not a research study. Experts reviewed evidence for GnRH agonist treatment in severe PMDD and created practical guidance, screening tools, and treatment algorithms for doctors.
What they found
GnRH agonists with hormone addback are established treatments for treatment-resistant PMDD. The main barrier is that many gynecologists and general psychiatrists lack knowledge about PMDD or training to prescribe this treatment. The guideline provides tools to help providers implement it.
What it means for you
GnRH agonists are an option when standard medications fail. The challenge is finding doctors trained to use them. This guideline aims to educate more providers. Cost can be a barrier depending on insurance coverage.
2021
Latest evidence cited
About the study
- Original title
- What's Stopping Us? Using GnRH Analogs With Stable Hormone Addback in Treatment-Resistant Premenstrual Dysphoric Disorder: Practical Guidelines and Risk-Benefit Analysis for Long-term Therapy
- Authors
- Wagner-Schuman M, Kania A, Barone JC et al.
- Journal
- The Journal of clinical psychiatry
- Year
- 2023
- Study design
- Guideline
- What was tested
- GnRH agonists with hormone addback.
- Read the paper
- doi.org/10.4088/jcp.22r14614
Topics
Related studies
Systematic review, 2024
What are the best treatments for PMDD and PMS?
Systematic review, 2022
What are the best treatments for PMDD and PMS?
Review, 2018
What are the most effective treatments for premenstrual syndrome and PMDD?
Review, 2015
What do we know about PMS and PMDD and how are they treated?
Review, 2008
What medications are FDA-approved for treating PMDD?
Randomised trial, 2003
What treatments work for PMS and PMDD?