Study, 1983
Does indoprofen help premenstrual migraine?
In this very small study, indoprofen appeared to reduce pain levels and decrease a prostaglandin marker in fluid from around the brain.
What they did
They gave 3 women with premenstrual migraine an intravenous dose of indoprofen 400 mg. They measured levels of a prostaglandin (PGF2 alpha) in cerebrospinal fluid (the fluid around the brain and spinal cord) at 0, 15, 30, and 45 minutes after injection. They also measured pain using a visual pain scale.
What they found
The treatment decreased levels of PGF2 alpha in the cerebrospinal fluid and decreased pain levels on the visual pain scale.
What it means for you
Indoprofen may help premenstrual migraine by reducing prostaglandins. However, this was only 3 women with no comparison group, so much larger studies are needed to know if this treatment really works.
3
Women with premenstrual migraine studied
400 mg
Indoprofen dose given intravenously
About the study
- Original title
- [New contributions on extinction tests of essential headache. II. The test with indoprofen]
- Authors
- Martelletti P, Romiti A, Gallo MF et al.
- Journal
- Bollettino della Societa italiana di biologia sperimentale
- Year
- 1983
- Study design
- Study
- What was tested
- Indoprofen 400 mg given into a vein
- Read the paper
- https://pubmed.ncbi.nlm.nih.gov/6578800/
Topics
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