Survey study, 2008
Are sex hormones different in women with PMS?
Women with PMS had more cells that respond to progesterone in their leg vein tissue compared to women without PMS. Cells responding to estrogen were the same in both groups.
What they did
Doctors compared tissue samples from leg veins in 20 women with PMS and 30 women without PMS, all taken during varicose vein surgery. They examined the tissue under a microscope using special staining to count how many muscle cells contained receptors for estrogen and progesterone.
What they found
Muscle cells with progesterone receptors were more abundant in women with PMS (343) than in women without PMS (240). There was no difference in estrogen receptors between the two groups.
What it means for you
The number of cells that can respond to progesterone, rather than the hormone levels themselves, may play a role in PMS. However, this is a small study looking only at leg vein tissue, which may not represent the whole body or tissues most involved in PMS symptoms.
20
Women with PMS
343
Progesterone receptors in PMS group
240
Receptors in non-PMS group
About the study
- Original title
- Sex hormone receptors in varicose veins of women with premenstrual syndrome
- Authors
- Łukasz Dzieciuchowicz, Małgorzata Kotwicka, M. Gabriel et al.
- Journal
- Phlebologie
- Year
- 2008
- Study design
- Survey study
- Participants
- 50
- What was tested
- None - tissue comparison study
- Read the paper
- doi.org/10.1055/s-0037-1622215
Topics
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