Skip to content

PTSD and trauma: what the research says

78 studies on ptsd and trauma in PMS and PMDD, each explained in plain English. 2 of them use the strongest designs: randomised trials and systematic reviews.

Survey study 42Cohort study 12Study 7Review 7Systematic review 4Randomised trial 2
Systematic review, 2025

Is there a link between stress, trauma, and premenstrual symptoms?

Yes. This meta-analysis of 66 studies with 38,344 people found a moderate positive link between stress and premenstrual symptoms. People with PMDD or PMS have significantly higher stress than others, and those with trauma history are more than twice as likely to have PMS.

Cohort study, 2014

Does childhood abuse increase the risk of PMS in adulthood?

Yes, women with childhood emotional abuse had 2.6 times higher PMS risk, and those with physical abuse had 2.1 times higher risk. This 14-year prospective study provides strong evidence.

Survey study, 2026

Does childhood trauma cause worse PMS, and can social support help?

In a study of 629 women in Iran, childhood trauma was associated with more severe PMS, while strong perceived social support was associated with less severe PMS. Social support appeared to reduce the negative effect of trauma on PMS.

Study, 2026

Do anxiety and depression get worse before your period if you already have a mental health condition?

Yes. If you have depression, bipolar disorder, or other mental health conditions, symptoms often worsen before your period due to hormone changes. This can affect how well treatments work.

Survey study, 2025

Do adverse childhood experiences increase PMS and menstrual symptoms in adulthood?

Yes. Women who experienced four or more adverse childhood experiences were nearly three times more likely to have severe premenstrual symptoms and more than five times as likely to have PMDD compared to those with fewer or no adverse experiences.

Cohort study, 2025

Do pain sensitivity and negative thinking explain how trauma and stress cause PMS or PMDD?

Yes. Both heightened pain sensitivity and negative thinking patterns mediate the connection between past trauma or stress and premenstrual disorder symptoms.

Survey study, 2025

What psychological and personal factors predict which university students will develop premenstrual syndrome?

High anger, low social support, childhood trauma, high stress, negative attitudes toward menstruation, and poor satisfaction with gender roles all predict PMS. However, results are limited to university students in one country.

Study, 2025

Do women with PMDD who experienced childhood trauma have more trouble recognizing emotions?

Yes. Women with PMDD who experienced childhood trauma, especially physical or sexual abuse, had significant difficulty recognizing emotions compared to women with PMDD who were not traumatized.

Systematic review, 2025

Are women with PMDD more likely to have experienced trauma in the past?

Yes. Across many studies, most women with PMDD reported past traumatic exposure, and they were about twice as likely to have a trauma history as women without PMDD.

Survey study, 2024

Did COVID-19 stress cause changes in menstrual cycles?

Yes, the pandemic was linked to menstrual cycle changes, and women with these changes were more likely to have depression and sleep problems, though the study can't prove stress caused the changes.

Cohort study, 2024

Is childhood trauma related to premenstrual disorders?

Yes. The study found a link between childhood trauma and premenstrual symptoms, especially in women with moderate-severe PMS or PMDD. Women with premenstrual worsening of other mental health problems also reported more childhood trauma than healthy women.

Cohort study, 2022

Do adverse childhood experiences increase risk of PMS and PMDD?

Women who experienced adverse childhood events had significantly higher risk of PMS and PMDD. Those with 4 or more such experiences had 2.46 times higher risk than those with none. The link was stronger for PMDD than for PMS.

Cohort study, 2022

How common are suicidal thoughts and self-harm in people with PMDD?

Suicidal thoughts, planning, and attempts are very common in people with PMDD. About 72% report lifetime suicidal thoughts, 49% report planning, and 34% report attempts.

Systematic review, 2022

Do anxiety disorders, PTSD and OCD get worse at certain points in the menstrual cycle?

For some women, yes. A review of 14 studies found that symptoms of several anxiety-related disorders tend to flare around the days before and after the period starts, but this pattern doesn't happen in every woman.

Survey study, 2021

Do women who experienced childhood maltreatment have more PMS?

Yes. Women with childhood maltreatment had 47% higher risk of PMS, with physical and emotional abuse showing the strongest associations.

Survey study, 2021

Did COVID-19 stress make PMS worse for young women?

Young women who experienced trauma symptoms from COVID-19 had more severe PMS symptoms than those without trauma. This observational study cannot prove that COVID stress causes worse PMS.

Lab study, 2020

Does anxiety sensitivity change during different parts of the menstrual cycle?

No, not much. Anxiety sensitivity remained relatively stable across the menstrual cycle phases tested, even in women with PTSD.

Cohort study, 2019

Does having PTSD or past trauma raise the risk of developing PMS later?

Yes. Women with trauma exposure or PTSD symptoms were more likely to develop PMS over time, and the more PTSD symptoms a woman had, the higher her risk.

Survey study, 2015

Does childhood stress cause menstrual cycle problems and lower fertility?

Women who experienced more childhood adversity had increased risk of fertility problems and missing periods. For each additional adverse experience, fertility risk rose 9% and missing periods 7%.

Case-control study, 2015

Does the menstrual cycle affect psychological symptoms differently in women with PTSD?

Psychological symptoms including depression and anxiety were worse during the early follicular phase compared to the midluteal phase. Women with PTSD showed worse phobic anxiety in the early follicular phase, while women without PTSD did not show this pattern.

Survey study, 2014

Is childhood abuse more common in women with PMDD?

Yes. Women with PMDD reported more childhood emotional abuse, physical abuse, sexual abuse, and emotional neglect than healthy women.

Cohort study, 2004

What risk factors cause PMDD to develop?

Traumatic events, anxiety disorders, and high daily stress significantly increase the risk of developing PMDD. Women who already had subthreshold PMDD at the start were at highest risk.

Cohort study, 2003

Is PTSD really connected to PMDD, or is it just coincidence?

The connection appears real. Women with PTSD had 11.7 times higher odds of PMDD, and most with both conditions reported childhood abuse or other trauma before PMDD started.

Review, 2000

What conditions beyond depression can antidepressants treat?

Newer antidepressants including SSRIs have FDA approval for several conditions including anxiety, obsessive-compulsive disorder, and panic disorder. Controlled studies also show they help premenstrual dysphoric disorder.

Study, 1990

Do women with a history of sexual trauma have more severe PMS than other women?

Yes. Women who reported sexual trauma had significantly more severe PMS and different PMS symptoms compared to women without that history.

Systematic review, 2026

Does childhood trauma increase the risk for PMS, PMDD, and related mood disorders?

Yes, childhood trauma appears to increase the risk for these mood disorders. Emotional abuse in childhood was most strongly linked. Childhood trauma may make women more sensitive to hormonal fluctuations during the menstrual cycle.

Survey study, 2026

Do girls who experienced childhood abuse or neglect have higher PMDD symptoms?

Yes. Girls who experienced childhood abuse or neglect reported higher PMDD symptoms compared to girls with limited abuse or neglect. This is a cross-sectional study, so we cannot know if maltreatment causes PMDD.

Cohort study, 2026

Can one questionnaire help doctors tell the difference between PMS, PMDD, and other mood disorders?

Researchers created a new questionnaire called COMPASS designed to help doctors distinguish PMS, PMDD, and perimenopause from conditions like depression, personality disorders, and trauma disorders that cause similar symptoms.

Study, 2026

Does transdermal estrogen work differently when applied as a gel compared to a patch in people with PMDD?

This is a clinical account suggesting estrogen may work differently in gel versus patch form depending on a person's nervous system state, especially in those with both PMDD and complex post-traumatic stress disorder. However, no research data is provided.

Interview study, 2026

Do women with premenstrual disorders who experienced emotional abuse see a connection between the two?

Women reported that their premenstrual symptoms resembled emotional patterns from their past abuse. The week before their period was when suppressed memories and feelings surfaced.

Cohort study, 2026

Can difficulty expressing emotions explain why childhood trauma increases PMS symptoms?

Yes. Childhood trauma increases difficulty identifying and expressing emotions (called alexithymia), which in turn increases PMS symptoms. This pathway explains part of the connection.

Survey study, 2026

Do difficult childhood experiences lead to worse PMS symptoms as an adult?

Yes. Among 399 university students in Türkiye, 71.7% had PMS symptoms, and those who reported difficult childhood experiences had worse PMS symptoms. Difficult childhood experiences and worse PMS were clearly linked.

Survey study, 2026

Do childhood adversity and psychological factors predict how severe PMS is?

Yes. Childhood adversity, difficulty expressing emotions, and psychological distress all significantly predict worse PMS.

Survey study, 2026

Does self-injury or difficult childhood experiences increase PMDD risk in adolescents?

Yes. This study found clear relationships between self-injurious behavior and PMDD, and between adverse childhood experiences and PMDD in adolescent girls, suggesting both are risk factors.

Survey study, 2026

Does childhood trauma cause worse PMS, and does dwelling on negative thoughts explain why?

Yes. Childhood trauma directly increases PMS severity, and rumination (dwelling on problems) partially explains this relationship.

Survey study, 2026

Do mindfulness, self-compassion and sense of coherence protect against severe PMS and PMDD?

Possibly yes. These psychological factors appeared to reduce the impact of stress and trauma on PMS and PMDD symptoms.

Survey study, 2026

Do childhood traumas affect how women cope with PMS?

Yes. Women who experienced childhood trauma reported worse ways of coping with PMS, and this was partly because of harmful beliefs about sexuality that developed from their trauma.

Survey study, 2026

Do trauma and stress worsen PMS symptoms, and does how you think about events matter?

Yes. Trauma and stress are strongly linked to worse PMS. The connection may work partly through how women interpret events and how much anger they feel.

Study, 2026

Could early stress or past trauma make PMDD symptoms worse later in the cycle?

This research offers a possible explanation for why PMDD symptoms vary so much, and why related conditions can worsen before a period. It is only a theory, not tested on patients, so we don't yet know if it is true.

Survey study, 2025

Is school bullying linked to premenstrual disorders in adolescent girls?

Yes, bullied girls were 3.15 times more likely to have premenstrual disorders. Social and verbal bullying had the strongest links.

Survey study, 2025

Is childhood trauma connected to premenstrual syndrome?

Yes, women with premenstrual syndrome experienced more childhood abuse and neglect, which were associated with more severe symptoms. The evidence is limited because only 437 women were surveyed in Turkey.

Survey study, 2025

Do PMS and menopausal symptoms make loneliness worse when women experience COVID-related stress?

Yes, PMS symptoms were associated with greater loneliness in pre-menopausal women with COVID-related stress, particularly through the emotional symptoms of PMS.

Survey study, 2025

Does childhood trauma affect PMS symptoms and how women experience childbirth?

Yes, childhood trauma, especially emotional and physical neglect, was linked to both PMS and traumatic childbirth perception. Reproductive health education appeared to reduce this effect.

Survey study, 2025

Is childhood trauma linked to premenstrual syndrome?

Yes. Women who experienced childhood trauma had more severe PMS symptoms. Higher trauma was associated with starting periods earlier, longer menstrual bleeding, and more severe PMS.

Cohort study, 2025

Does trait anger explain why trauma and stress lead to premenstrual disorder symptoms?

Trait anger appears to be the key factor linking trauma and stress to premenstrual disorder symptoms. Anger affects the actual symptoms themselves, while rumination and sense of control only affect how women perceive the severity of their symptoms.

Review, 2025

How do trauma and sensory processing affect PMDD symptoms?

Trauma-related changes to the brain heighten sensitivity to sensory input and emotions, which can worsen PMDD symptoms during the luteal phase. Understanding trauma and sensory factors may improve how PMDD is diagnosed and treated.

Survey study, 2024

Is suicidal thinking more common in women with premenstrual disorders?

Yes. Women with premenstrual disorders have higher rates of suicidal thinking and attempts, especially if they are young (18-25), unemployed, have low income, or have depression or anxiety.

Survey study, 2024

Does childhood abuse increase premenstrual syndrome through suicidal thoughts?

Yes. Women who experienced childhood abuse were more likely to have PMS, partly through increased suicidal thoughts. Different types of abuse had slightly different patterns.

Survey study, 2023

Does childhood trauma make premenstrual symptoms worse in women with PMDD?

Yes, women with PMDD who experienced childhood adversity had stronger mood worsening during the premenstrual phase compared to those without. However, this was a small study with no control group, so we need more research to confirm the findings.

Survey study, 2023

Does childhood trauma increase the risk of PMDD?

Yes. Women who experienced childhood trauma were about three times more likely to have PMDD symptoms than those who did not experience childhood trauma.

Randomised trial, 2023

What does research show about PMDD neurochemistry?

The provided text does not include results from a PMDD neurochemistry study. It discusses unrelated research on other topics.

Review, 2023

How does the stress response system affect depression during reproductive stages like PMDD?

The HPA axis, which controls the stress response, changes during reproductive stages and plays an important role in depression risk at vulnerable times like PMDD, after birth, and perimenopause. Past stress and trauma exposure increase this risk.

Survey study, 2022

Do women with PMS have increased risk of suicidal thoughts?

Yes. Nearly one-third of women with PMS symptoms reported new or worsening suicidal thoughts in the week before their period. Women with depression history, current depression, and childhood trauma were at highest risk.

Survey study, 2022

Do childhood trauma and certain personality traits make PMS or PMDD symptoms worse?

Yes, childhood maltreatment and personality traits like high worry and low self-directedness were linked to worse PMS or PMDD. This is based on questionnaires in one country, so it shows correlation but not definite cause.

Survey study, 2022

Is early life trauma more common in women with PMDD?

Yes. 83% of women with PMDD experienced early life trauma, much higher than the general Australian population, suggesting a strong link between childhood trauma and PMDD.

Survey study, 2021

Do adolescents with PMS have more childhood trauma and mental health problems?

Yes. Adolescents with PMS had higher scores for childhood trauma and mental health symptoms than those without PMS, though the connection was weak.

Survey study, 2021

Are childhood trauma and stress linked to PMDD?

Yes. Sexual and psychological abuse in childhood, plus current stress, increase PMDD risk mainly through depression.

Survey study, 2021

Do adverse childhood experiences increase the risk of PMS?

Yes, women who experienced more adverse things in childhood had significantly higher PMS symptoms. The evidence is fairly clear, but the study only included young university women and cannot prove childhood experiences cause PMS.

Review, 2021

How does the menstrual cycle affect anxiety and PTSD symptoms?

The menstrual cycle and its hormones affect anxiety and PTSD symptoms. The clearest finding is premenstrual worsening of anxiety, and estradiol may help with trauma memory processing.

Survey study, 2020

Does a history of childhood trauma make premenstrual symptoms worse?

Yes, women who reported more childhood trauma also reported more severe premenstrual symptoms, and this link seemed to be fully explained by difficulties managing emotions.