Randomised trial, 1995
Does fluoxetine reduce PMS mood symptoms?
Yes. The study found that fluoxetine reduced premenstrual feelings of sadness, tension, and irritability.
What they did
313 women with PMS were randomly assigned to receive either 20 mg or 60 mg of fluoxetine (an antidepressant) in a double-blind trial.
What they found
Fluoxetine reduced premenstrual symptoms of sadness, tension, and irritability.
What it means for you
An antidepressant may help with PMS mood and tension symptoms. Main limit: the abstract is incomplete, so the full results and which dose was more effective are not clear.
313
women randomized
20 mg
fluoxetine low dose
60 mg
fluoxetine high dose
About the study
- Original title
- Fluoxetine as a Treatment for PMS
- Authors
- Peter Roy‐Byrne
- Journal
- Journal watch
- Year
- 1995
- Study design
- Randomised trial
- Participants
- 313
- What was tested
- Fluoxetine 20 mg or 60 mg
- Read the paper
- doi.org/10.1056/jp199507010000005
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